A SYNTHETIC LETHAL SCREEN FOR SNAIL-INDUCED ENZALUTAMIDE RESISTANCE IDENTIFIES JAK/STAT SIGNALING AS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally.The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor signaling, including androgen deprivation therapy pl

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Estimation of Private Consumption Function of Iran: Autoregressive Distributed Lag Approach to Co-integration

Considering consumption due to its pivotal role in economic growth and also aggregate demand and specially its long-run analysis have always been in the Cheese Grater center of attention.In this study, we have estimated private consumption function, using ARDL approach and employing annual data during 1978-2012.Short-run elasticity of private consu

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Hysteria: history of a conceptual and clinical pathomorphosis

Introduction Transhistorical psychiatry defends that a psychic alteration can be interpreted as a cultural, historical and personal construction, subject to incessant variations.Objectives A journey through the history of the disorder and the successive pathomorphoses it has undergone could provide us with a better understanding of it and explain t

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Effect of some Improvement Works on the Floristic Composition of the Vegetal Cover in Nardus stricta Grasslands

The study of the floristic composition of Nardus stricta grasslands improved through fertilisation, amendment and re-sowing for 18 years points out a structural change of the vegetal cover compared to the initial Gift Cards state of the floristic composition.During this time interval, the share of Nardus stricta dropped from 40 to 14% in the varian

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